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Intact glutathione is poorly membrane-permeant and extracellular glutathione is degraded by gamma-glutamyl transpeptidase before its amino acids are reimported (Zhang, Forman and Choi, Methods in Enzymology, 2005), whereas cysteine-delivery agents bypass that step

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An additional study with 100 and 200 M doses of APR-246 showed a dose-dependent decrease in G1 that is both p53 and P72R-independent (Supplementary Fig